MATRIX METALLOPROTEINASES (MMPs) AND CHRONIC INFLAMMATORY CONDITIONS

Certain MMPs have pro-inflammatory molecules as their targets. Their action activates these pro-inflammatory molecules into bio-active inflammatory mediators. MMPs 2,3,7,9 and TNF attract and recruit inflammatory cells (monocytes, macrophages and neutrophils) to an area of inflammation by activating chemical attractants called chemokines (KC, fractalkine and TGFbeta).

These inflammatory cells contain inflammatory mediators (cytokines) and pro-TNF.  MMPs then activatepro-TNF to TNFalpha-a very powerful cytokine that not only is inflammatory in nature, but also stimulates the production of more MMPs thereby amplifying a chronic vicious cycle of inflammation.

System Saver's ingredients intervene in this process by inhibiting MMPs thereby slowing inflammatory cell infiltration and cytokine  and TNF production.  This disrupts the cycle of inflammation common to many chronic incurable disorders.

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