MATRIX METALLOPROTEINASES (MMPs) AND TISSUE DEGENERATION
MMPs such as collagenase, gelatinase, elastase, aggrecanase, matrilysin and stromelysin have, as their targets, structurally critical macromolecules found in cartilage, bone, ligament, blood vessels, nerve matrix, lung matrix, bronchi, lamina and the extra-cellular matrix. These MMPs are involved in the ongoing remodeling of these structures. Regeneration is supported by providing a supply of building blocks (in the case of cartilage-chondroitin, glucosamine, polysulfatedglycosaminoglycans, hyaluronic acid) and nutrients. When regeneration of these tissues is in balance with their degradation, a healthy steady state exists.
Factors such as aging (wear and tear), trauma, repetitive stress, athletic activity, exogenous toxins and endogenous free radicals induce and upregulate MMP production. MMP upregulation results in an increase in tissue destruction, inflammatory processes and induction of more MMP synthesis, thereby amplifying these processes. As this cycle amplifies and perpetuates itself, the regenerative process is overwhelmed and tissue destruction and degeneration occurs.
System Saver's MMP inhibitory ingredients can intervene in this chronic vicious cycle and allow restoration of the balanced healthy state. Unlike nutraceutical building blocks, System Saver acts on the degenerative processes, before the destruction occurs.
When used regularly, the regenerative processes can dominate the degenerative, thereby slowing the damage from aging, repetitive stress (occupational or exercise induced) and other insults.
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