Research Studies & Articles

MATRIX METALLOPROTEINASES (MMPs) AND TISSUE DEGENERATION

MMPs such as collagenase, gelatinase, elastase, aggrecanase, matrilysin and stromelysin have, as their targets, structurally critical macromolecules found in cartilage, bone, ligament, blood vessels, nerve matrix, lung matrix, bronchi, lamina and the extra-cellular matrix.  These MMPs are involved in the ongoing remodeling of these structures. Regeneration is supported by providing a supply of building blocks (in the case of cartilage-chondroitin, glucosamine, polysulfatedglycosaminoglycans, hyaluronic acid) and nutrients. When regeneration of these tissues is in balance with their degradation, a healthy steady state exists.

Factors such as aging (wear and tear), trauma, repetitive stress, athletic activity, exogenous toxins and endogenous free radicals induce and upregulate MMP production.  MMP upregulation results in  an increase in tissue destruction, inflammatory processes and induction of more MMP synthesis, thereby amplifying these processes. As this cycle amplifies and perpetuates itself, the regenerative process is overwhelmed and tissue destruction and degeneration occurs.

System Saver's MMP inhibitory ingredients can intervene in this chronic vicious cycle and allow restoration of the balanced healthy state.  Unlike nutraceutical building blocks, System Saver acts on the degenerative processes, before the destruction occurs.

When used regularly, the regenerative processes can dominate the degenerative, thereby slowing the damage from aging, repetitive stress (occupational or exercise induced) and other insults.

To read the studies, click on each title.

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# Web Link Hits
1   Link   Inhibition of activator protein-1 binding activity and phosphatidylinositol 3-kinase pathway by nobiletin, a polymethoxy flavonoid, results in augmentation of tissue inhibitor of metalloproteinases-1 production and suppression of production of matrix
837
2   Link   A citrus flavonoid, nobiletin, suppresses production and gene expression of matrix metalloproteinase 9/gelatinase B in rabbit synovial fibroblasts.
898
3   Link   Aggrecanases and cartilage matrix degradation.
966
4   Link   Nobiletin, a citrus polymethoxy flavonoid, suppresses gene expression and production of aggrecanases-1 and -2 in collagen-induced arthritic mice.
895
5   Link   The regulation of the ADAMTS4 and ADAMTS5 aggrecanases in osteoarthritis: a review.
964
6   Link   Green tea polyphenol epigallocatechin-3-gallate (EGCG) differentially inhibits interleukin-1 beta-induced expression of matrix metalloproteinase-1 and -13 in human chondrocytes.
753
7   Link   Selective inhibition of ADAMTS-1, -4 and -5 by catechin gallate esters.
970
8   Link   Catechins from green tea (Camellia sinensis) inhibit bovine and human cartilage proteoglycan and type II collagen degradation in vitro.
877
9   Link   A double blind, randomized, placebo controlled study of the efficacy and safety of 5-Loxin for treatment of osteoarthritis of the knee.
813
10   Link   Oral administration of diferuloylmethane (curcumin) suppresses proinflammatory cytokines and destructive connective tissue remodeling in experimental abdominal aortic aneurysms.
802
11   Link   Role of Matrix Metalloproteinase Inhibitors in Preventing Abdominal Aortic Aneurysm
1009
12   Link   Inhibition of interleukin-1-stimulated MAP kinases, activating protein-1 (AP-1) and nuclear factor kappa B (NF-kappa B) transcription factors down-regulates matrix metalloproteinase gene expression in articular chondrocytes.
773
13   Link   Suppression of NF-kappaB activation by curcumin leads to inhibition of expression of cyclo-oxygenase-2 and matrix metalloproteinase-9 in human articular chondrocytes: Implications for the treatment of osteoarthritis.
758
14   Link   Effects of curcumin (diferuloylmethane) on nuclear factor kappaB signaling in interleukin-1beta-stimulated chondrocytes.
962